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KMID : 0359920150340020093
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Korean Journal of Nephrology
2015 Volume.34 No. 2 p.93 ~ p.97
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Transforming growth factor-β receptor 2 gene polymorphisms are associated with end-stage kidney disease
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Ki Hye-Jin
Kim Se-Yun
Lee Sang-Ho
Moon Ju-Young
Jeong Kyung-Hwan
Lee Tae-Won
Ihm Chun-Gyoo
Kim Su-Kang
Chung Joo-Ho
Kang Sun-Woo
Kim Tae-Hee
Kim Yeong-Hoon
Kim Yang-Gyun
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Abstract
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Background: Transforming growth factor-beta (TGF-β) is a multifunctional cytokine involved in immune disorders, cancer, asthma, lung fibrosis, and chronic kidney disease, and its signal pathways are considered crucial mediators of a variety
of cellular processes. In addition, several recent studies have reported that TGF-β receptor (TGF-βR) gene polymorphism is associated with chronic kidney disease. However, the association between end-stage renal disease (ESRD) and the TGF-β gene polymorphism has not been sufficiently investigated. In this study, we hypothesized that polymorphisms of the TGF-β ligands or their receptors may be related to ESRD.
Methods: We assessed the relationship between four single-nucleotide polymorphisms (SNPs) in the TGF-βR2 and TGF-β2 genes and ESRD, in 312 patients with ESRD and 258 controls.
Results: Compared with the control participants, the frequencies of the TGF-βR2 (rs764522*C) and TGF-βR2 (rs3087465*G) alleles were significantly higher in the patients with ESRD. Genotyping analysis demonstrated that two SNPs in TGF-βR2 of
the four SNPs included in the study were significantly associated with ESRD in the codominant 1 [rs764522, odds ratio (OR)=1.65; rs3087465, OR=1.63], dominant (rs764522, OR=1.63; rs3087465, OR=1.57), and log-additive (rs764522, OR=1.54;
rs3087465, OR=1.39) models after adjusting for age and sex.
Conclusion: We suggest that TGF-βR2 polymorphisms (rs764522 and rs3087465) increase the risk of development of ESRD.
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KEYWORD
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End-stage renal disease, Fibrosis, Transforming growth factor-beta
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